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The Will Wang Lab
at Sanford Burnham Prebys Medical Discovery Institute

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Research

Our goal is to understand how every cell in the body works together to maintain function and health.

 

The Wang lab focuses on neuromuscular disorders with an emphasis on the normal role of immune cells in supporting efficient regenerative processes and how these mechanics go awry in autoimmune diseases and aging.

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We use state-of-the-art spatial omics and neural network analysis to probe cellular interactions at single cell resolution. 

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We are making discoveries in multicellular mechanisms that transform our understanding of:

  • How stem cells carry out the process of healing

  • The degenerative tissue microenvironment that lead to chronic disease

  • Cellular and molecular basis of biological aging

Our Interdisciplinary Approach

Select Publications

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Stankiewicz LN, Salim K, Flaschner EA, Wang YX, Edgar JM, Durland LJ, Lin BZB, Bingham GC, Major MC, Jones RD, Blau HM, Rideout EJ, Levings MK, Zandstra PW, Rossi FMV. Sex-biased human thymic architecture guides T cell development through spatially defined niches. Developmental Cell 2025;60:152-169.e8. https://doi.org/10.1016/j.devcel.2024.09.011.

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Link

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