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For a complete list of our publications and links to access our papers


Nair S, Ameen M, Sundaram L, Pampari A, Schreiber J, Balsubramani A, Wang YX, Burns DM, Blau HM, Karakikes I, Wang KC, Kundaje A. Transcription factor stoichiometry, motif affinity and syntax regulate single-cell chromatin dynamics during fibroblast reprogramming to pluripotency. bioRxiv 2023:2023.10.04.560808.

Bakooshli M.A., Wang Y.X., Monti E., Su S., Kraft P., Nalbandian M., Alexandrova L., Wheeler J.R., Vogel H., Blau H.M. Regeneration of neuromuscular synapses after acute and chronic denervation by inhibiting the gerozyme 15-prostaglandin dehydrogenase. Sci. Transl. Med. 15, eadg1485(2023). DOI:10.1126/scitranslmed.adg1485

Zengel J., Wang Y.X., Seo J.W., Ning K., Hamilton J.N., Wu B., Raie M., Holbrook C., Su S., Clements D.R., Pillay S., Puschnik A.S., Winslow M.M., Idoyaga J., Nagamine C.M., Sun Y., Mahajan V.B., Ferrara K.W., Blau H.M., Carette J.E., Hardwiring tissue-specific AAV transduction in mice through engineered receptor expression. Nature Methods 2023:1–12.

Stankiewicz LN, Salim K, Flaschner EA, Wang YX, Edgar JM, Lin BZ, et al. Sex biased human thymic architecture guides T cell development through spatially defined niches. bioRxiv 2023:2023.04.13.536804.

Groppa E., Martini P., Derakhshan N., Theret M., Ritso M., Tung L.W., Wang Y.X., Soliman H., Hamer M.S., Stankiewicz L., Eisner C., Erwan L.N., Chang C., Yi L., Yuan J.H., Kong S., Weng C., Adams J., Chang L., Peng A., Blau H.M., Romualdi C., Rossi F.M.V., Spatial compartmentalization of signaling imparts source-specific functions on secreted factors. Cell Reports 2023;42

Togninalli, M., Ho, A.T.V., Madl, C.M., Holbrook, C.A., Wang, Y.X., Magnusson, K.E.G., Kirillova, A., Chang, A., and Blau, H.M. (2023). Machine learning-based classification of binary dynamic fluorescence signals reveals muscle stem cell fate transitions in response to pro-regenerative niche factors. npj Regenerative Medicine. 2023 8, Article number: 4



Wang, Y.X., Holbrook, C.A., Hamilton, J.N., Garoussian, J., Afshar, M., Su, S., Schürch, C.M., Lee, M.Y., Goltsev, Y., Kundaje, A., et al. (2022). A single cell spatial temporal atlas of skeletal muscle reveals cellular neighborhoods that orchestrate regeneration and become disrupted in aging. bioRxiv. 2022.06.10.494732.

Palla A.R., Hilgendorf K.I., Yang A.V., Kerr J.P., Hinken A.C., Demeter J., Kraft P., Mooney N.A., Yucel N., Burns D.M., Wang Y.X., Jackson P.K., Blau H.M. (2022) Primary cilia on muscle stem cells are critical to maintain regenerative capacity and are lost during aging. Nat Commun. 2022 Mar 17;13(1):1439.



Wang, Y.X., and Blau, H.M. (2021). Reversing aging for heart repair. Science, 373(6562), 1439–1440.


Madl C.M., Flaig I.A., Holbrook C.A., Wang Y.X., and Blau H.M. (2021) Biophysical matrix cues from the regenerating niche direct muscle stem cell fate in engineered microenvironments. Biomaterials. Jun 14;275:120973. 


Markov G.J., Mai T., Nair S., Shcherbina A., Wang Y.X., Burns D.M., Kundaje A., and Blau H.M. (2021) AP-1 is a temporally regulated dual gatekeeper of reprogramming to pluripotency. Proc Natl Acad Sci USA. 2021 Jun 8;118(23):e2104841118.


Palla, A.R., Ravichandran, M., Wang, Y.X., Alexandrova, L., Yang, A.V., Kraft, P., Holbrook, C.A., Schürch, C.M., Ho, A.T.V., and Blau, H.M. (2021) Inhibition of Prostaglandin Degrading Enzyme 15-PGDH Rejuvenates Aged Muscle Mass and Strength. Science 2021 Jan 29;371(6528):eabc8059


Yucel, N.*, Wang, Y.X.*, Mai, T., Porpiglia, E., Lund, P.J., Markov, G., Garcia, B.A., Bendall, S.C., Angelo, M., and Blau, H.M. (2019). Glucose metabolism drives histone acetylation landscape transitions that dictate muscle stem cell function. Cell Reports 27(13), 3939-3955. 


Wang, Y.X.*, Feige, P.*, Brun, C.E., Hekmatnejad, B., Dumont, N.A., Renaud, J.-M., Faulkes, S., Guindon, D.E., and Rudnicki, M.A. (2019). EGFR-Aurka Signaling Rescues Polarity and Regeneration Defects in Dystrophin-Deficient Muscle Stem Cells by Increasing Asymmetric Divisions. Cell Stem Cell 24, 419-432.e6. 



Wang, Y.X., and Blau, H.M. (2018). Macrophages rescue injured engineered muscle. Nature Biomedical Engineering 2, 890–891.


Brun, C.E., Wang, Y.X., and Rudnicki, M.A. (2018). Single EDL Myofiber Isolation for Analyses of Quiescent and Activated Muscle Stem Cells. in Cellular Quiescence, (Humana Press, New York, NY), pp. 149–159.


Ho, A.T.V., Palla, A.R., Blake, M.R., Yucel, N.D., Wang, Y.X., Magnusson, K.E.G., Holbrook, C.A., Kraft, P.E., Delp, S.L., and Blau, H.M. (2017). Prostaglandin E2 is essential for efficacious skeletal muscle stem-cell function, augmenting regeneration and strength. Proc Natl Acad Sci U.S.A. 114, 6675–6684. 


Sincennes, M.C., Wang, Y.X., and Rudnicki, M.A. (2017). Primary Mouse Myoblast Purification using Magnetic Cell Separation. in Muscle Stem Cells, (Humana Press, New York, NY), pp. 41–50. 



Dumont, N.A.*, Wang, Y.X.*, von Maltzahn, J., Pasut, A., Bentzinger, C.F., Brun, C.E., and Rudnicki, M.A. (2015). Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division. Nature Medicine 21, 1455–1463. 


Dumont, N.A., Wang, Y.X., and Rudnicki, M.A. Intrinsic and extrinsic mechanisms regulating satellite cell function. Development. 2015 May 1;142(9):1572-1581. 



Wang, Y.X., Dumont, N.A., and Rudnicki, M.A. Muscle Stem Cells At-a-glance. Journal of Cell Science. 127 (21), 4543-4548. 


Bentzinger C.F., von Maltzahn J., Dumont N.A., Stark D.A., Wang Y.X., Nhan K., Frenette J., Cornelison D.D., and Rudnicki M.A. (2014) Wnt7a stimulates myogenic stem cell motility and engraftment resulting in improved muscle strength. Journal of Cell Biology. 205(1):97-111. 



Bentzinger, C.F., Wang, Y.X., Dumont, N.A. and Rudnicki, M.A. (2013). Cellular dynamics in the muscle satellite cell niche.  EMBO Reports. 14(12):1062-72. 


Wang, Y.X., Bentzinger, C.F., and Rudnicki, M.A. (2013). Treating muscular dystrophy by stimulating intrinsic repair. Regenerative Medicine. 8(3):237-40. 


Bentzinger, C.F., Wang, Y.X., von Maltzahn, J., Soliemani V.D., Yin H. and Rudnicki, M.A. (2013). Fibronectin within the niche regulates Wnt7a signaling and satellite cell expansion. Cell Stem Cell, 12(1):75-87. 


Wang, Y.X., Bentzinger, C.F., and Rudnicki, M.A. (2013). Molecular regulation of determination in asymmetrically dividing muscle stem cells. Cell Cycle. 12(1), 3–4. 


Bentzinger, C.F., Wang, Y.X., von Maltzahn, J., and Rudnicki, M.A. (2012). The emerging biology of muscle stem cells: Implications for cell-based therapies. Bioessays. 35(3):231-41. 


Kawabe Y.I., Wang Y.X., McKinnell I.W., Bedford M.T., and Rudnicki M.A. (2012).  Carm1 Regulates Pax7 Transcriptional Activity through MLL1/2 Recruitment during Asymmetric Satellite Stem Cell Divisions. Cell Stem Cell, 11(3), 333–345.


Wang, Y.X., and Rudnicki, M.A. (2012). Satellite cells, the engines of muscle repair. Nature Reviews Molecular Cell Biology, 13(2), 127–133. 


Bentzinger, C.F., Wang, Y.X., and Rudnicki, M.A. (2012). Building muscle: molecular regulation of myogenesis. Cold Spring Harbor Perspectives in Biology, 4(2). pii: a0083 

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