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  • Writer's pictureWill Wang

Publication: Boosting AAV-mediated gene delivery using engineered receptor expression

Our collaborative publication in Nature Methods with Jan Carette's lab at Stanford University. Using a new mouse model featuring tissue-specific over expression of the AAV receptor, we show that precise control of where AAV is able to deliver its cargo. Importantly, we can target specific stem cell populations (quiescent muscle stem cells) that were not efficiently targeted by AAV. This work has been several years in the making including a key experiment that was completed the night before the campus shut down during the pandemic. Kudos to Jimmy Zengel and other co-authors for this exciting work!

Find the paper, open access, here


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